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Endocrine Abstracts

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ea0019p300 | Reproduction | SFEBES2009

Plasma kisspeptin levels in hypertensive diseases of pregnancy and the identification of kisspeptin in amniotic fluid

Nijher G , Dhillo W , Chaudhri O , Murphy K , Ramachandran R , Fowler A , Chinthapalli K , Patterson M , Thompson E , Williamson C , Kumar S , Ghatei M , Bloom S

Kisspeptin, encoded by the KiSS-1 gene activates the G protein coupled receptor 54 (GPR54). The kisspeptin/GPR54 system plays an essential role regulating reproductive development. The human placenta has a high expression of both the KiSS-1 and GPR54 genes. Plasma kisspeptin levels increase several thousand fold in pregnancy. The physiological role of kisspeptin in pregnancy is not clear. Kisspeptin causes vasoconstriction during in vitro studies and may play a r...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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